- Genetic factors
- Accidental bite of cheeks while eating or speaking or even while eating sharp food items
- Viral infections
- Low body immunity
- Medical disorders like crohn’s disease, Celiac Diseases, Ulcerative Colitis, lichen planus, Steven Johnson syndrome, and other Blood disorders.
- Vitamin deficiency especially vitamin C and B.
- Hormonal abnormalities, especially among women
- Cigarette smoking